Cankdeska Cikana; Fort Peck Community College; Haskell Indian Nations University; Keweenaw Bay Ojibwa Community College; Northwest Indian College; Southwestern Indian Polytechnic Institute; Stone Child College; Woodlands Wisdom/Leech Lake; and IHS/DHHS/CDC will collaborate to develop a national science-based diabetes prevention education curriculum for Native American students in grades K-12. The curriculum design will enhance the understanding and appreciation of this devastating disease by the development of culturally appropriate activities and biomedical career awareness opportunities. The goal is two-fold: to enhance the students, family and community members as well as teachers; understanding of diabetes in order to prevent the development of diabetes and to help Tribal members better manage diabetes and, to increase the numbers of Native Americans entering the health science professions. The curriculum will be aligned with national and state teaching standards and benchmarks and will include: culturally sensitive teaching materials designed to enhance the understanding attitudes and knowledge levels of students in grades K-12; hands-on, science based materials that reflect traditional learning styles emphasizing visual, spatial and perceptual modes of learning; multi-dimensional lesson plans facilitating ease of use in a variety of classrooms and core subject areas; Multimedia technology; and evaluation tools for pre and post-testing for determining the progress, attitude change and knowledge increase in students.